Why Low Histamine?
New food sensitivities? Reactions to things you used to tolerate?
You’re not alone—and you’re not imagining it.
When the immune system becomes dysregulated, it can lose some of its natural balance. Mast cells—the body’s front-line defenders—may start releasing histamine more easily, even in response to everyday foods, environments, or stress.
Histamine itself isn’t “bad.” It’s a natural compound that helps with digestion, immune signaling, and cell communication.
Interestingly, it is also present in nearly every food to some degree because it forms naturally as the amino acid histidine breaks down. Normally, our body's enzymes keep histamine in check. But if our baseline histamine is already high due to immune overactivity, adding in high-histamine foods can tip the balance and trigger symptoms including migraines, vertigo, fatigue, rashes, digestive issues, heart palpitations, and new food sensitivities.
That was my experience. After years of trying autoimmune diets (AIP, paleo, elimination) with little relief, I discovered the problem wasn’t autoimmunity—it was immune reactivity. A low-histamine, immune-stabilizing approach finally gave my body the chance to calm down and reset.
Unlike autoimmune diets that stimulate or modulate immunity, a low histamine protocol focuses on reducing excess activation—lowering inflammation, easing the load on the system, and supporting stability. For many, it can be a key step toward feeling better.
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Best wishes in your healing journey,